Publications

Journal Article

Polymorphism in Pharmaceutical Drugs by Supercritical CO2 Processing: Clarifying the Role of the Antisolvent Effect and Atomization Enhancement
CRYSTAL GROWTH \& DESIGN, 16, 6222-6229 11 2016
Miguel Rodrigues , Joao M. Tiago , Andreia Duarte , Vitor Geraldes , Henrique A. Matos , Edmundo Azevedo

Insight into the Mechanisms of Cocrystallization of Pharmaceuticals in Supercritical Solvents
CRYSTAL GROWTH \& DESIGN, 15, 3175-3181 7 2015
Luis Padrela , Miguel Rodrigues , Joao Tiago , Sitaram P. Velaga , Henrique A. Matos , Edmundo Azevedo

New Thermoresistant Polymorph from CO2 Recrystallization of Minocycline Hydrochloride
PHARMACEUTICAL RESEARCH, 31, 3136-3149 11 2014
Miguel Rodrigues , Joao M. Tiago , Luis Padrela , Henrique A. Matos , Teresa G. Nunes , Lidia Pinheiro , Antonio J. Almeida , Edmundo Azevedo

Tuning physicochemical properties of theophylline by cocrystallization using the supercritical fluid enhanced atomization technique
JOURNAL OF SUPERCRITICAL FLUIDS, 86, 129-136 2 2014
Luis Padrela , Miguel Rodrigues , Joao Tiago , Sitaram P. Velaga , Henrique A. Matos , Edmundo Azevedo

Single-Step Co-Crystallization and Lipid Dispersion by Supercritical Enhanced Atomization
CRYSTAL GROWTH \& DESIGN, 13, 4940-4947 11 2013
Joao M. Tiago , Luis Padrela , Miguel Rodrigues , Henrique A. Matos , Antonio J. Almeida , Edmundo Azevedo

The Importance of Heat Flow Direction for Reproducible and Homogeneous Freezing of Bulk Protein Solutions
BIOTECHNOLOGY PROGRESS, 29, 1212-1221 9 2013
Miguel Rodrigues , Gustavo Balzan , Monica Rosa , Diana Gomes , Edmundo Azevedo , Satish K. Singh , Henrique A. Matos , Vitor Geraldes

Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 82, 392-400 10 2012
Miguel Rodrigues , Lara Figueiredo , Luis Padrela , Ana Cadete , Joao Tiago , Henrique A. Matos , Edmundo Azevedo , Helena F. Florindo , Lidia Goncalves , Antonio J. Almeida

Powder X-ray diffraction method for the quantification of cocrystals in the crystallization mixture
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 38, 923-929 8 2012
Luis Padrela , Edmundo Azevedo , Sitaram P. Velaga

Theophylline polymorphs by atomization of supercritical antisolvent induced suspensions
JOURNAL OF SUPERCRITICAL FLUIDS, 58, 303-312 9 2011
Miguel Rodrigues , Luis Padrela , Vitor Geraldes , Jose Santos , Henrique A. Matos , Edmundo Azevedo

Screening for pharmaceutical cocrystals using the supercritical fluid enhanced atomization process
JOURNAL OF SUPERCRITICAL FLUIDS, 53, 156-164 6 2010
Luis Padrela , Miguel Rodrigues , Sitaram P. Velaga , Anabela Fernandes , Henrique A. Matos , Edmundo Azevedo

Formation of indomethacin-saccharin cocrystals using supercritical fluid technology
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 38, 9-17 8 2009
Luis Padrela , Miguel Rodrigues , Sitaram P. Velaga , Henrique A. Matos , Edmundo Azevedo

Calculation of Solid-Liquid-Gas Equilibrium for Binary Systems Containing CO2
INDUSTRIAL \& ENGINEERING CHEMISTRY RESEARCH, 48, 4579-4586 5 2009
Jindui Hong , Hui Chen , Jun Li , Henrique A. Matos , Edmundo Azevedo

Anti-solvent effect in the production of lysozyme nanoparticles by supercritical fluid-assisted atomization processes
JOURNAL OF SUPERCRITICAL FLUIDS, 48, 253-260 4 2009
Miguel Rodrigues , Jun Li , Luis Padrela , Antonio J. Almeida , Henrique A. Matos , Edmundo Azevedo

Using N-2- or CO2-assisted atomization process to produce polyethylene glycol microparticles
CHEMICAL ENGINEERING RESEARCH \& DESIGN, 85, 987-995 7 2007
L. Zhao , J. Li , Miguel Rodrigues , Henrique A. Matos , Edmundo Azevedo

Vapor-liquid equilibria and volume expansion of the tetrahydrofuran/CO2 system: Application to a SAS-atomization process
JOURNAL OF SUPERCRITICAL FLUIDS, 41, 343-351 7 2007
Jun Li , Miguel Rodrigues , Alexandre Paiva , Henrique A. Matos , Edmundo Azevedo

Efficiency of water removal from water/ethanol mixtures using supercritical carbon dioxide
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING, 23, 205-212 4 2006
MA Rodrigues , J Li , AJ Almeida , HA MATOS , Edmundo Azevedo

Binary solid-liquid-gas equilibrium of the tripalmitin/CO2 and ubiquinone/CO2 systems
FLUID PHASE EQUILIBRIA, 241, 196-204 3 2006
J Li , Miguel Rodrigues , Alexandre Paiva , HA MATOS , Edmundo Azevedo

VLE of carbon dioxide/ethanol/water: Applications to volume expansion evaluation and water removal efficiency
INDUSTRIAL \& ENGINEERING CHEMISTRY RESEARCH, 44, 6751-6759 8 2005
J Li , Miguel Rodrigues , HA MATOS , Edmundo Azevedo

Modeling of the PGSS process by crystallization and atomization
AICHE JOURNAL, 51, 2343-2357 8 2005
J Li , Miguel Rodrigues , Alexandre Paiva , HA MATOS , Edmundo Azevedo

High pressure phase equilibrium for delta-tocopherol + CO2
FLUID PHASE EQUILIBRIA, 216, 53-57 2 2004
P Pereira , B Coto , C Menduina , Edmundo Azevedo , MN da Ponte

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